Parkinson disease: Progress towards a molecular biomarker for Parkinson disease.

作者信息

Foulds Penelope, Mann David M A, Mitchell J Douglas, Allsop David

出版信息

Nat Rev Neurol. 2010 Jul;6(7):359-61. doi: 10.1038/nrneurol.2010.78.

DOI:10.1038/nrneurol.2010.78

PMID:20639912

Abstract

摘要

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本文引用的文献

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High-molecular-weight beta-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients.

FASEB J. 2010-3-25

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DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease.

Brain. 2010-2-15

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The genetics of Parkinson's syndromes: a critical review.

Curr Opin Genet Dev. 2009-6

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Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration.

Exp Neurol. 2008-10

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Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease.

Biochem Biophys Res Commun. 2006-10-13

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Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease.

J Biol Chem. 2006-10-6

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Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease.

Biochem Biophys Res Commun. 2006-7-7

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Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease.

FASEB J. 2006-3

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Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma.

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