Institute of Neuroscience & Physiology, Department of Psychiatry & Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Biomark Med. 2010 Oct;4(5):671-81. doi: 10.2217/bmm.10.84.
This article focuses on biochemical markers that may be used in the diagnostics of Parkinson's disease and associated disorders, and to identify early cases and stratify patients into subgroups. We present an updated account of some currently available candidate fluid biomarkers, and discuss their diagnostic performance and limitations. We also discuss some of the general problems with Parkinson's disease biomarkers and possible ways of moving forward. It may be concluded that a diagnostically useful fluid biomarker for Parkinson's disease is yet to be identified. However, some interesting candidates exist and may prove useful in the future, alone or when analyzed together in patterns.
本文重点介绍了可能用于帕金森病及相关疾病诊断的生化标志物，并识别早期病例和对患者进行亚组分类。我们介绍了一些当前可用的候选液体现有生物标志物，并讨论了它们的诊断性能和局限性。我们还讨论了一些帕金森病生物标志物的常见问题以及可能的前进方向。可以得出结论，用于帕金森病的具有诊断意义的液体现有生物标志物尚未被确定。然而，存在一些有前景的候选标志物，它们将来可能会单独或通过模式分析而具有一定的应用价值。
