帕金森病的生化前驱生物标志物。
Biochemical premotor biomarkers for Parkinson's disease.
机构信息
Paracelsus-Elena-Klinik and Georg August University Goettingen, Kassel, Germany.
出版信息
Mov Disord. 2012 Apr 15;27(5):644-50. doi: 10.1002/mds.24956.
Abstract
A biomarker is a biological characteristic that is objectively measured and evaluated as an indicator of normal biological or pathologic processes or of pharmacologic responses to a therapeutic intervention. We reviewed the current status of target protein biomarkers (eg, total/oligomeric α-synuclein and DJ-1) in cerebrospinal fluid, as well as on unbiased processes that can be used to discover novel biomarkers. We have also provide details about strategies toward potential populations/models and technologies, including the need for standardized sampling techniques, to pursue the identification of new biochemical markers in the premotor stage of Parkinson's disease in the future.
摘要
生物标志物是一种客观测量和评估的生物学特征，可作为正常生物学或病理过程的指标，或作为对治疗干预的药理反应的指标。我们回顾了目前在脑脊液中目标蛋白生物标志物（如总/寡聚α-突触核蛋白和 DJ-1）的现状，以及可用于发现新生物标志物的无偏过程。我们还详细介绍了针对潜在人群/模型和技术的策略，包括需要标准化采样技术，以在未来帕金森病的运动前期识别新的生化标志物。
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