Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec.
Epidemiol Infect. 2010 Dec;138(12):1679-90. doi: 10.1017/S0950268810001639. Epub 2010 Jul 20.
A systematic review of outbreak and non-outbreak studies of infections caused by extraintestinal pathogenic Escherichia coli (ExPEC) was conducted. This review examines the epidemiology, seasonality, source or mode of transmission, and temporal changes, based on E. coli serogroup, in ExPEC causing sporadic vs. outbreak-associated infections. Twelve outbreak and 28 non-outbreak studies were identified. The existence of ExPEC outbreaks was well supported. Three of four outbreak reports indicated peak periods during the winter months. Serogroups associated with outbreak infections ranged from 1% to 26% (average 11·4%) vs. (range 1-15%, average 3·5%) for serogroups associated with sporadic infections; the distribution of serogroups also differed for outbreak and non-outbreak infections. Study authors indicated that the outbreaks may have resulted from foodborne transmission, but direct evidence was unavailable. This review provides evidence that the epidemiology of endemic vs. epidemic ExPEC infections differs; however, study reporting quality limited epidemiological inferences.
进行了一次关于肠外致病性大肠杆菌（ExPEC）感染暴发和非暴发研究的系统综述。本综述根据导致散发感染与暴发相关感染的大肠杆菌血清群，考察了感染的流行病学、季节性、来源或传播方式以及时间变化。确定了 12 项暴发和 28 项非暴发研究。存在 ExPEC 暴发的证据确凿。四份暴发报告中的三份表明，冬季是高峰期。与暴发感染相关的血清群范围为 1%至 26%（平均 11.4%），而与散发感染相关的血清群范围为 1-15%（平均 3.5%）；暴发和非暴发感染的血清群分布也不同。研究作者表示，这些暴发可能是由食源性传播引起的，但没有直接证据。本综述提供了证据表明，地方性与流行性 ExPEC 感染的流行病学不同；然而，研究报告的质量限制了流行病学推论。
