Department of Endocrinology, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Rua Professor Lima Basto, Lisboa, Portugal.
Eur J Endocrinol. 2010 Oct;163(4):631-5. doi: 10.1530/EJE-10-0449. Epub 2010 Jul 19.
Iodine is the key element for thyroid hormone synthesis, and its deficiency, even moderate, is harmful in pregnancy, when needs are increased, because of its potential deleterious effects on fetal brain development. In Portugal, no recent data on iodine intake exists. The objective of this countrywide study was to analyze iodine status in pregnant Portuguese women in order to propose adequate measures to the health authorities.
Using a fast colorimetric method, urine iodine concentration (UIC) was evaluated in 3631 pregnant women followed in 17 maternity hospitals from hinterland and coastal areas in Continental Portugal and the Portuguese islands of Açores and Madeira.
Median UIC value was 84.9 μg/l (range 67.6-124.1) in Continental Portugal, 69.5 μg/l in Madeira, and 50.0 μg/l in Açores. The percentage of satisfactory values (>150 μg/l) was 16.8, ranging from 8.8 to 34.1 in the Continent, and being 8.2 in Madeira and 2.3 in Açores. The percentage of values below 50 μg/l was 23.7, ranging from 14.0 to 37.4 in the Continent, 33.7 in Madeira, and 50.0 in Açores.
Our results point to an inadequate iodine intake in pregnant women assisted in most Portuguese maternity hospitals. Considering the potential deleterious effects of inadequate iodine supply in pregnancy, iodine supplementation is strongly recommended in this period of life.
碘是合成甲状腺激素的关键元素，即使是轻度的碘缺乏，在妊娠期间也是有害的，因为此时需要量增加，而碘缺乏可能对胎儿大脑发育产生有害影响。在葡萄牙，目前没有关于碘摄入量的最新数据。本项全国性研究的目的是分析葡萄牙孕妇的碘营养状况，以便向卫生部门提出适当的措施。
采用快速比色法，检测了来自葡萄牙内陆和沿海地区 17 家产科医院的 3631 名孕妇的尿碘浓度（UIC）。
葡萄牙大陆的 UIC 中位数为 84.9μg/L（范围 67.6-124.1），马德拉为 69.5μg/L，亚速尔群岛为 50.0μg/L。满意值（>150μg/L）的百分比为 16.8%，范围为 8.8%-34.1%，大陆为 8.2%，马德拉为 33.7%，亚速尔群岛为 2.3%。<50μg/L 的值百分比为 23.7%，范围为 14.0%-37.4%，大陆为 33.7%，马德拉为 50.0%。
我们的研究结果表明，大多数葡萄牙产科医院的孕妇碘摄入不足。鉴于妊娠期间碘供应不足可能产生有害影响，强烈建议在此期间补充碘。
