Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Irwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea.
Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Soonchunhyang University, Seoul, Republic of Korea.
Eur J Nutr. 2016 Mar;55(2):469-475. doi: 10.1007/s00394-015-0864-7. Epub 2015 Mar 7.
Proper iodine intake is important during pregnancy for both fetal neurodevelopment and maternal thyroid function. Korea is known as a high iodine intake area. However, there are no data regarding iodine status in pregnant Korean women. Therefore, we evaluated the iodine status of pregnant women in Korea by measuring urine iodine concentration.
This study had an observational, prospective design. We enrolled 344 healthy pregnant women who visited Samsung Medical Center in Korea for a routine antenatal checkup between April 2012 and September 2013. We measured iodine and creatinine concentration (Cr) in spot urine samples and TSH level in serum at the time of enrollment.
The median urinary iodine concentration (UIC) and UIC adjusted by Cr were 427.3 μg/L and 447.9 μg/gCr, respectively. There was no difference in median UIC according to trimester of pregnancy (P value = 0.953). Serum TSH level was not different according to UIC level when subjects were grouped according to WHO iodine recommendations (P value = 0.401).
The median UIC of healthy pregnant women in Korea was 427.3 μg/L and 447.9 μg/gCr, which are more than adequate according to WHO criteria. Considering the wide range of UIC, we recommend active education about adequate iodine intake during pregnancy in areas where iodine intake is more than adequate according to WHO criteria.
怀孕期间适当的碘摄入对胎儿神经发育和母体甲状腺功能都很重要。韩国是碘摄入量较高的地区。然而，目前尚无关于韩国孕妇碘状况的数据。因此，我们通过测量尿碘浓度来评估韩国孕妇的碘状况。
本研究采用观察性、前瞻性设计。我们招募了 344 名在韩国三星医疗中心接受常规产前检查的健康孕妇，这些孕妇在 2012 年 4 月至 2013 年 9 月期间就诊。我们在入组时测量了尿样中的碘和肌酐浓度（Cr）以及血清中的 TSH 水平。
尿碘浓度（UIC）中位数和 Cr 校正的 UIC 中位数分别为 427.3μg/L 和 447.9μg/gCr，妊娠各期 UIC 中位数无差异（P 值=0.953）。根据世界卫生组织（WHO）碘建议将研究对象按 UIC 水平分组时，血清 TSH 水平与 UIC 水平无差异（P 值=0.401）。
韩国健康孕妇的 UIC 中位数为 427.3μg/L 和 447.9μg/gCr，根据 WHO 标准，这两者都很充足。鉴于 UIC 范围较广，我们建议在根据 WHO 标准碘摄入量充足的地区，积极开展关于孕妇充足碘摄入的教育。
