Elisabeth Bruyère Research Institute, Ottawa, Ontario, Canada.
CMAJ. 2010 Sep 7;182(12):E542-8. doi: 10.1503/cmaj.091304. Epub 2010 Jul 19.
In Canada, vaccination coverage for seasonal influenza among health care personnel remains below 50%. The objective of this review was to determine which seasonal influenza vaccination campaign or campaign components in health care settings were significantly associated with increases in influenza vaccination among staff.
We identified articles in eight electronic databases and included randomized controlled trials, controlled before-and-after studies and studies with interrupted time series designs in our review. Two reviewers independently abstracted the data and assessed the risk of biases. We calculated risk ratios and 95% confidence intervals for randomized controlled trials and controlled before-and-after studies and described interrupted time series studies.
We identified 99 studies evaluating influenza vaccination campaigns for health care workers, but only 12 of the studies were eligible for review. In nonhospital health care settings, including long-term care facilities, campaigns with a greater variety of components (including education or promotion, better access to vaccines, legislation or regulation and/or role models) were associated with higher risk ratios (i.e, favouring the intervention group). Within hospital settings, the results reported for various types of campaigns were mixed. Many of the criteria for assessing risk of bias were not reported.
Campaigns involving only education or promotion resulted in minimal changes in vaccination rates. Further studies are needed to determine the appropriate components and combinations of components in influenza vaccination campaigns for health care personnel.
在加拿大,医护人员接种季节性流感疫苗的覆盖率仍低于 50%。本研究旨在确定在医疗环境中哪些季节性流感疫苗接种活动或活动内容与提高员工流感疫苗接种率显著相关。
我们在 8 个电子数据库中确定了文章,并将随机对照试验、对照前后研究和具有时间序列中断设计的研究纳入我们的综述。两名审查员独立提取数据并评估偏倚风险。我们计算了随机对照试验和对照前后研究的风险比和 95%置信区间,并描述了时间序列中断研究。
我们确定了 99 项评估医护人员流感疫苗接种活动的研究,但只有 12 项研究符合审查条件。在非医院医疗保健环境中,包括长期护理设施,具有更多种类组件(包括教育或宣传、更好地获得疫苗、立法或监管和/或榜样)的活动与更高的风险比相关(即支持干预组)。在医院环境中,各种类型活动报告的结果参差不齐。许多评估偏倚风险的标准都没有报告。
仅涉及教育或宣传的活动导致疫苗接种率的微小变化。需要进一步的研究来确定医护人员流感疫苗接种活动的适当组件和组件组合。