Avenel-Audran Martine, Dutartre Hervé, Goossens An, Jeanmougin Michel, Comte Christelle, Bernier Claire, Benkalfate Lamia, Michel Maryse, Ferrier-Lebouëdec Marie Christine, Vigan Martine, Bourrain Jean Luc, Outtas Omar, Peyron Jean Louis, Martin Ludovic
Service de Dermatologie, Centre Hospitalier Universitaire, Angers CEDEX 9, France.
Arch Dermatol. 2010 Jul;146(7):753-7. doi: 10.1001/archdermatol.2010.132.
Octocrylene is a new emerging photoallergen. We report and discuss 50 cases of photoallergic contact dermatitis from octocrylene use and/or positive photopatch test reactions to this UV filter and draw attention to the unexpected association in adults with a history of photoallergic contact dermatitis from ketoprofen.
Patients were divided in 3 groups: group A comprised 11 children; group B, 28 adults with a history of photoallergy from sunscreen products; and group C, 14 adults systematically tested with octocrylene because of a history of photoallergy from ketoprofen. All patients but 3 in group C had positive test reactions to octocrylene. Ten of 11 children in group A and 9 of 28 adults in group B had positive patch test reactions to octocrylene. One child in group A, the other 19 adults in group B, and 11 of 14 adults in group C had positive photopatch test reactions to octocrylene. All adults in group C and 24 of 28 adults in group B had a history of photoallergy from ketoprofen and positive patch test or photopatch test reactions to other allergens that are often positive in patients with photoallergy from ketoprofen, especially fragrance components.
Octocrylene appears to be a strong allergen leading to contact dermatitis in children and mostly photoallergic contact dermatitis in adults with an often-associated history of photoallergy from ketoprofen. Patients with photoallergy from ketoprofen frequently have positive photopatch test reactions to octocrylene. These patients need to be informed of sunscreen products not containing octocrylene, benzophenone-3, or fragrances.
二乙氨羟苯甲酰是一种新出现的光变应原。我们报告并讨论了50例因使用二乙氨羟苯甲酰和/或对该紫外线过滤剂进行光斑贴试验呈阳性反应而导致的光变应性接触性皮炎病例，并提请注意在有酮洛芬所致光变应性接触性皮炎病史的成年人中出现的意外关联。
患者分为3组：A组包括11名儿童；B组为28名有防晒产品光过敏史的成年人；C组为14名因有酮洛芬所致光过敏史而系统接受二乙氨羟苯甲酰检测的成年人。除C组3名患者外，所有患者对二乙氨羟苯甲酰的检测反应均呈阳性。A组11名儿童中的10名以及B组28名成年人中的9名对二乙氨羟苯甲酰的斑贴试验反应呈阳性。A组1名儿童、B组另外19名成年人以及C组14名成年人中的11名对二乙氨羟苯甲酰的光斑贴试验反应呈阳性。C组所有成年人以及B组28名成年人中的24名有酮洛芬所致光过敏史，且对其他过敏原的斑贴试验或光斑贴试验反应呈阳性，这些过敏原在有酮洛芬所致光过敏的患者中通常呈阳性，尤其是香料成分。
二乙氨羟苯甲酰似乎是一种强效变应原，可导致儿童发生接触性皮炎，在成年人中大多导致光变应性接触性皮炎，且这些成年人通常有酮洛芬所致光过敏史。有酮洛芬所致光过敏的患者对二乙氨羟苯甲酰的光斑贴试验反应常常呈阳性。需要告知这些患者不含二乙氨羟苯甲酰、二苯甲酰甲烷或香料的防晒产品。
