Alaluusua S, Takei T, Ooshima T, Hamada S
Department of Pedodontics and Orthodontics, University of Helsinki, Finland.
Arch Oral Biol. 1991;36(4):251-5. doi: 10.1016/0003-9969(91)90094-b.
A total of 157 isolates of mutants streptococci from plaque and saliva of 94 children were studied for their serotypes, mutacin production, frequency and spectrum of activity. Of these isolates 71% were identified as serotype c and 22% as serotype e. Serotypes f, d and g, and one untypable strain made up about 7% of the isolates. More than one serotype was found in 13% of the children. Mutacin was produced by 83% of the isolates against one or more of the 14 indicator strains representing mutants streptococci. Streptococcus sanguis, Strep. oralis, Strep. gordonii, Strep. salivarius and Strep. pyogenes. Isolates that had a broad inhibitory spectrum also produced larger inhibition zones than isolates that inhibited fewer strains. When evaluating the effect of mutacin in vivo on plaque ecology, it was found that the counts of mutans streptococci or the proportion of mutans streptococci in the total streptococcal count of plaque did not differ between plaques containing strains that produced much mutacin and those with little production. The findings also failed to reveal an association between caries experience and mutacin activity.
对来自94名儿童牙菌斑和唾液中的157株变异链球菌分离株进行了血清型、变链菌素产生情况、活性频率和活性谱的研究。在这些分离株中，71%被鉴定为c血清型，22%为e血清型。f、d和g血清型以及一株无法分型的菌株约占分离株的7%。13%的儿童中发现了不止一种血清型。83%的分离株对代表变异链球菌的14种指示菌株中的一种或多种产生了变链菌素，这些指示菌株包括血链球菌、口腔链球菌、戈登链球菌、唾液链球菌和化脓性链球菌。具有广泛抑制谱的分离株产生的抑菌圈也比抑制菌株较少的分离株更大。在评估变链菌素在体内对菌斑生态的影响时，发现产生大量变链菌素的菌株所在菌斑与产生少量变链菌素的菌株所在菌斑相比，变异链球菌的数量或变异链球菌在菌斑总链球菌计数中的比例并无差异。研究结果也未能揭示龋齿经历与变链菌素活性之间的关联。
