Centre for Phytomedicine Research, Department of Botany, University of Fort Hare, Alice, South Africa.
Pharm Biol. 2010 May;48(5):568-76. doi: 10.3109/13880200903207094.
Aqueous extract of Bulbine natalensis Baker (Asphodelaceae) stem at 25, 50 and 100 mg/kg body weight was investigated for anabolic and androgenic effects in male Wistar rats. Sixty male rats were grouped into four (A-D) consisting of 15 each. Group A (control) was orally treated with 0.5 mL of distilled water for 14 days while groups B, C and D were treated like the control except they received 0.5 mL containing 25, 50, and 100 mg/kg body weight of the extract respectively. All the doses of the extract increased (P <0.05) the testicular-body weight ratio as well as alkaline phosphatase activity, glycogen, sialic acid, protein, and cholesterol content of the testes except the single administration of 100 mg/kg body weight which compared well (P>0.05) with the controls for glycogen and cholesterol. The testicular and serum testosterone concentration were increased except in the 100 mg/kg body weight where the effect on the tissue and serum hormone did not manifest until after the first and seven daily doses respectively. Testicular acid phosphatase activity, serum follicle stimulating and luteinizing hormone concentrations also increased at all the doses except in the 100 mg/kg body weight where the effect on the enzyme and the hormone did not manifest until after seven days. The increases were most pronounced in the 50 mg/kg body weight extract treated animals. The results indicate anabolic and androgenic activities of Bulbine natalensis stem in male rat testes with the 50 mg/kg body weight of the extract exhibiting the highest anabolizing and androgenic activities. These activities further support the folkloric use of the plant most especially at 50 mg/kg body weight in the management of male sexual dysfunction in South Africa.
纳塔尔布氏 Bulbine（百合科）茎的水提取物在 25、50 和 100mg/kg 体重时，对雄性 Wistar 大鼠的合成代谢和雄激素作用进行了研究。将 60 只雄性大鼠分为四组（A-D），每组 15 只。A 组（对照组）经口给予 0.5ml 蒸馏水，共 14 天；B、C 和 D 组处理方式与对照组相同，只是分别给予 0.5ml 含有 25、50 和 100mg/kg 体重的提取物。除了 100mg/kg 体重的单次给药与对照组相比，对糖原和胆固醇没有影响外，所有提取物剂量均能提高（P<0.05）睾丸-体重比以及碱性磷酸酶活性、糖原、唾液酸、蛋白质和胆固醇的含量。睾丸和血清睾丸激素浓度增加，除了在 100mg/kg 体重时，组织和血清激素的作用分别在第一次和第七天剂量后才表现出来。睾丸酸性磷酸酶活性、血清卵泡刺激素和黄体生成素浓度也在所有剂量下增加，除了在 100mg/kg 体重时，对酶和激素的作用分别在第七天后才表现出来。在 50mg/kg 体重提取物处理的动物中，增加最为明显。结果表明，纳塔尔布氏 Bulbine 茎在雄性大鼠睾丸中具有合成代谢和雄激素活性，50mg/kg 体重的提取物表现出最高的同化和雄激素活性。这些活性进一步支持了该植物在南非民间医学中，特别是在 50mg/kg 体重时，用于治疗男性性功能障碍的用途。
