Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Pharm Biol. 2010 Mar;48(3):333-6. doi: 10.3109/13880200903133829.
No phytochemical investigation regarding Scrophularia striata Boiss. (Scrophulariaceae) has been performed, although several reports about other Scrophularia species have been published. The inhibitory effects of aerial parts of S. striata on matrix metalloproteinase expression elaborate a new approach to treat variety of malignant and inflammatory disorders. Five known compounds, including cinnamic acid, three flavonoids (quercetine, isorhamnetin-3-O-rutinoside and nepitrin) and one phenyl propanoid glycoside (acteoside 1) were isolated from S. striata Boiss. by chromatographic techniques and the structures of compounds were characterized by spectroscopic methods. This is the first report regarding the isolation of these compounds from S. striata.
尚未对 Scrophularia striata Boiss.（玄参科）进行植物化学研究，尽管已经发表了一些关于其他 Scrophularia 物种的报道。S. striata 的地上部分对基质金属蛋白酶表达的抑制作用为治疗多种恶性和炎症性疾病提供了一种新的方法。通过色谱技术从 S. striata Boiss. 中分离出 5 种已知化合物，包括肉桂酸、3 种类黄酮（槲皮素、异鼠李素-3-O-芸香糖苷和尼泊替林）和 1 种苯丙素糖苷（acteoside 1），并通过光谱方法鉴定了化合物的结构。这是首次从 S. striata 中分离出这些化合物的报道。
