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引用本文的文献

1
[Expression of interferon-λ1 in respiratory epithelial cells in children with human rhinovirus infection].[人鼻病毒感染儿童呼吸道上皮细胞中干扰素-λ1的表达]
Zhongguo Dang Dai Er Ke Za Zhi. 2019 Dec;21(12):1177-1181. doi: 10.7499/j.issn.1008-8830.2019.12.005.

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Interferon (IFN)-λ is a potential mediator in lupus nephritis.干扰素（IFN）-λ是狼疮性肾炎的潜在介质。
Lupus Sci Med. 2016 Nov 22;3(1):e000170. doi: 10.1136/lupus-2016-000170. eCollection 2016.
2
Targeting IFN-λ: therapeutic implications.靶向干扰素-λ：治疗意义。
Expert Opin Ther Targets. 2016 Dec;20(12):1425-1432. doi: 10.1080/14728222.2016.1241242. Epub 2016 Oct 11.
3
Dexamethasone decreases IL-29 expression in house dust mite-stimulated human bronchial epithelial cells.地塞米松可降低屋尘螨刺激的人支气管上皮细胞中白细胞介素-29的表达。
J Huazhong Univ Sci Technolog Med Sci. 2015 Dec;35(6):823-827. doi: 10.1007/s11596-015-1513-3. Epub 2015 Dec 16.
4
Respiratory syncytial virus genomic load and disease severity among children hospitalized with bronchiolitis: multicenter cohort studies in the United States and Finland.毛细支气管炎住院儿童的呼吸道合胞病毒基因组载量与疾病严重程度：美国和芬兰的多中心队列研究
J Infect Dis. 2015 May 15;211(10):1550-9. doi: 10.1093/infdis/jiu658. Epub 2014 Nov 25.
5
In vitro anti-influenza A activity of interferon (IFN)-λ1 combined with IFN-β or oseltamivir carboxylate.干扰素（IFN）-λ1联合IFN-β或羧基奥司他韦的体外抗甲型流感病毒活性
Antiviral Res. 2014 Nov;111:112-20. doi: 10.1016/j.antiviral.2014.09.008. Epub 2014 Sep 20.
6
Interferon lambda 1-3 expression in infants hospitalized for RSV or HRV associated bronchiolitis.婴幼儿住院毛细支气管炎中 RSV 或 HRV 相关的干扰素 lambda 1-3 的表达。
J Infect. 2014 May;68(5):467-77. doi: 10.1016/j.jinf.2013.12.010. Epub 2014 Jan 2.
7
Interferon induction and function at the mucosal surface.在黏膜表面诱导干扰素及发挥作用。
Immunol Rev. 2013 Sep;255(1):25-39. doi: 10.1111/imr.12101.
8
Interferon-lambda in the immune response to hepatitis B virus and hepatitis C virus.干扰素 lambda 在乙型肝炎病毒和丙型肝炎病毒免疫反应中的作用。
J Interferon Cytokine Res. 2010 Aug;30(8):585-90. doi: 10.1089/jir.2010.0060.
9
Mechanisms of type III interferon expression.III 型干扰素表达的机制。
J Interferon Cytokine Res. 2010 Aug;30(8):573-8. doi: 10.1089/jir.2010.0063.
10
Human interferon-lambda3 is a potent member of the type III interferon family.人干扰素-λ3是III型干扰素家族的一个强效成员。
Genes Immun. 2009 Mar;10(2):125-31. doi: 10.1038/gene.2008.87. Epub 2008 Nov 6.

[呼吸道合胞病毒感染患儿呼吸道上皮细胞中干扰素-λ1的表达及其与呼吸道合胞病毒载量的关系]

[Expression of interferon-λ1 in respiratory epithelial cells of children with RSV infection and its relationship with RSV load].

作者信息

Tao Mei-Ting, Xie Ya-Ping, Liu Shu-Ping, Chen Hao-Feng, Huang Han, Chen Min, Zhong Li-Li

机构信息

Children's Medical Center, Hunan Provincial People's Hospital, Changsha 410005, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2017 Jun;19(6):677-681. doi: 10.7499/j.issn.1008-8830.2017.06.013.

DOI:10.7499/j.issn.1008-8830.2017.06.013
PMID:28606236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7390299/
Abstract

OBJECTIVE

To investigate the expression of IFN-λ1 in respiratory epithelial cells of children with respiratory syncytial virus (RSV) infection and its relationship with RSV load.

METHODS

The nasopharyngeal swabs were collected from the children who were hospitalized with respiratory tract infection from June 2015 to June 2016. A direct immunofluorescence assay was used to detect the antigens of seven common respiratory viruses (including RSV) in the nasopharyngeal swabs. A total of 120 children who were only RSV positive were selected as the RSV infection group. A total of 50 children who had negative results in the detection of all viral antigens were selected as the healthy control group. Fluorescence quantitative real-time PCR was used to determine the RSV load and the expression of IFN-λ1 mRNA in the nasopharyngeal swabs of children in the two groups.

RESULTS

The expression of IFN-λ1 in the RSV infection group was significantly higher than that in the healthy control group (P<0.05). The expression of IFN-λ1 was positively correlated with RSV load (r=0.56, P<0.05).

CONCLUSIONS

RSV can induce the expression of IFN-λ1 in respiratory epithelial cells, suggesting that IFN-λ1 may play an important role in anti-RSV infection.

摘要

目的

探讨呼吸道合胞病毒（RSV）感染患儿呼吸道上皮细胞中IFN-λ1的表达及其与RSV载量的关系。

方法

收集2015年6月至2016年6月因呼吸道感染住院患儿的鼻咽拭子。采用直接免疫荧光法检测鼻咽拭子中7种常见呼吸道病毒（包括RSV）的抗原。选取120例仅RSV阳性患儿作为RSV感染组。选取50例所有病毒抗原检测均为阴性的患儿作为健康对照组。采用荧光定量实时PCR法检测两组患儿鼻咽拭子中RSV载量及IFN-λ1 mRNA的表达。

结果

RSV感染组IFN-λ1的表达明显高于健康对照组（P<0.05）。IFN-λ1的表达与RSV载量呈正相关（r=0.56，P<0.05）。

结论

RSV可诱导呼吸道上皮细胞中IFN-λ1的表达，提示IFN-λ1可能在抗RSV感染中发挥重要作用。