Vo D T, Hsu W H, Abu-Basha E A, Martin R J
Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.
J Vet Pharmacol Ther. 2010 Aug;33(4):315-22. doi: 10.1111/j.1365-2885.2010.01160.x.
Fleas are significant ectoparasites of small animals. They can be a severe irritant to animals and serve as a vector for a number of infectious diseases. In this article, we discuss the pharmacological characteristics of four insect nicotinic acetylcholine receptor (nAChR) agonists used as flea adulticides in dogs and cats, which include three neonicotinoids (imidacloprid, nitenpyram, and dinotefuran) and a macrocyclic lactone (spinosad). Insect nAChR agonists are one of the most important classes of insecticides, which are used to control sucking insects on both plants and animals. These novel compounds provide a new approach for practitioners to safely and effectively eliminate adult fleas.
跳蚤是小型动物重要的体表寄生虫。它们会给动物带来严重刺激，还能作为多种传染病的传播媒介。在本文中，我们讨论了四种用作犬猫杀成蚤剂的昆虫烟碱型乙酰胆碱受体（nAChR）激动剂的药理学特性，其中包括三种新烟碱类（吡虫啉、烯啶虫胺和呋虫胺）和一种大环内酯类（多杀菌素）。昆虫nAChR激动剂是最重要的杀虫剂类别之一，用于防治植物和动物身上的刺吸式昆虫。这些新型化合物为从业者安全有效地消灭成蚤提供了新方法。
