Int J Immunopathol Pharmacol. 2010 Apr-Jun;23(2):627-32. doi: 10.1177/039463201002300225.
The use of thermal infrared (IR) imaging together with the study of the thermal recovery from a controlled cold challenge has been proposed in the diagnosis and follow-up of therapeutic response of Raynaud's Phenomenon (RP) and Systemic Sclerosis (SSc). The controlled cold challenge test usually performed during IR investigations may induce a RP in patients with the latter condition. In our Institution we routinely perform capillaroscopy and thermal IR to follow-up SSc patients. In this paper, we describe the thermal recovery patterns shown by two SSc patients (a 40 year-old male with diffuse variant of SSc and a 71 year-old female with a limited variant of SSc) who presented ischemic and paroxysmal RP attack while recovering from the routine controlled cold challenge test. During RP attack, the cutaneous temperature of some fingers continued to decrease for some minutes even after the cessation of the cold stress. To the best of our knowledge, to date, no literature report has documented the thermal behaviour of SSc patients' fingers which occasionally present ischemic and paroxysmal response. Triggering of ischemic RP attack appears to not rely only on morphological and structural finger impairment, but also upon other aspects, like the emotional attitude of the subject and the possible discomfort experienced with the proceeding of the functional cold stress test.
热红外（IR）成像的使用以及对受控冷挑战后热恢复的研究已被提议用于诊断和随访雷诺现象（RP）和系统性硬化症（SSc）的治疗反应。在进行 IR 研究时，通常会进行受控冷挑战测试，这可能会引起后者疾病患者的 RP。在我们的机构中，我们常规进行毛细血管镜检查和热 IR 随访 SSc 患者。在本文中，我们描述了两名 SSc 患者（一名 40 岁男性，弥漫性 SSc 变异型和一名 71 岁女性，局限性 SSc 变异型）在从常规受控冷挑战测试中恢复时出现的缺血性和阵发性 RP 发作的热恢复模式。在 RP 发作期间，一些手指的皮肤温度在寒冷应激停止后仍继续下降几分钟。据我们所知，迄今为止，尚无文献报道记录 SSc 患者手指的热行为，这些患者的手指偶尔会出现缺血性和阵发性反应。缺血性 RP 发作的触发似乎不仅依赖于手指的形态和结构损伤，还依赖于其他方面，例如受试者的情绪态度以及随着功能性冷应激测试的进行可能感到的不适。
