College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Key Laboratory of Medical Chemistry and Molecular Diagnosis, Ministry of Education, Baoding 071002, PR China.
Ultrason Sonochem. 2011 Jan;18(1):42-4. doi: 10.1016/j.ultsonch.2010.05.010. Epub 2010 Jun 2.
Synthesis of Mannich bases related to gramine via Mannich reaction of secondary amine, formaldehyde and indole or N-methylindole can be carried out in 69-98% yields in acetic acid aqueous solution at 35°C under ultrasound irradiation. Compared with the method using stirring, the present procedure provided several advantages such as milder conditions, shorter reaction time and higher yield.
在醋酸水溶液中，于 35°C 下超声辐射，通过仲胺、甲醛和吲哚或 N-甲基吲哚的曼尼希反应，可以以 69-98%的产率合成与禾本科有关的曼尼希碱。与使用搅拌的方法相比，本方法具有条件温和、反应时间短、产率高等优点。
