Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.
Ultrason Sonochem. 2011 Mar;18(2):520-6. doi: 10.1016/j.ultsonch.2010.09.007. Epub 2010 Sep 29.
A solvent-free procedure for the synthesis of 3-substituted indole derivates from indoles and nitroalkenes under ultrasound irradiation is described. Control experiments disclosed besides mechanical effects, namely agitation, sonochemical effects are the main forces to drive the reaction. In the method, 2-chloroethanol was used to prepare a wide variety of 3-substituted indole derivates. This procedure only need equimolar amounts of reaction substrates and can be readily scaled up.
超声辐射下无溶剂合成 3-取代吲哚衍生物的方法描述了从吲哚和硝基烯烃合成 3-取代吲哚衍生物的无溶剂方法。除机械作用（即搅拌）外，对照实验还揭示了声化学效应是推动反应的主要力量。在该方法中，使用 2-氯乙醇制备了各种各样的 3-取代吲哚衍生物。该方法仅需要等摩尔量的反应底物，并且易于放大。
