Yu Bo, Xu Guoxing, Liu Xiaofan, Yin Wen, Chen Hao, Sun Baoqing
1Department of Emergency, Tongji Medical College, Huazhong University of Science and Technology, The Central Hospital of Wuhan, 26 Shengli Street, Wuhan, 430014 Hubei province China.
2Department of Allergy, Tongji Medical College, Huazhong University of Science and Technology, The Central Hospital of Wuhan, 26 Shengli Street, Wuhan, 430010 Hubei Province China.
Allergy Asthma Clin Immunol. 2019 Dec 30;15:84. doi: 10.1186/s13223-019-0400-z. eCollection 2019.
Kimura's disease (KD) is a rare chronic inflammatory disease with unknown etiology. It usually manifests as a painless soft tissue mass or subcutaneous nodule on one side of the patient's head and/or neck and rarely affects multiple parts of the body. The disease is more common among young Asian males.
A 57-year-old Chinese woman complained of multiple masses on her body surface. Ultrasonography was used to examine the retroperitoneal, bilateral neck, bilateral supraclavicular, bilateral axillary, and bilateral inguinal superficial lymph nodes. Enlargement of multiple lymph nodes was found in all areas. Many solid nodules were also found in the right parotid gland and right posterior neck area, respectively. Numerous solid nodules were seen on the left chest wall. Laboratory tests showed that the percentage of eosinophils in the whole blood was 39.40%, total immunoglobulin E (IgE) level was > 5000 kU/L, and serum special IgE to Phadiatop (inhaled allergens) and fx5 (food allergens) were 1.01 and 1.04 kUA/L, respectively. After a complete examination, the masses located in the right neck, retroauricular and left axillary regions, and left chest wall were resected directly. Postoperative pathological findings revealed KD.
The case discussed in this study is extremely rare and did not meet the common affected areas and age characteristics of KD. This presentation can be used to improve disease awareness among physicians.
木村病（KD）是一种病因不明的罕见慢性炎症性疾病。它通常表现为患者头部和/或颈部一侧无痛性软组织肿块或皮下结节，很少累及身体多个部位。该疾病在年轻亚洲男性中更为常见。
一名57岁中国女性主诉体表有多个肿块。采用超声检查腹膜后、双侧颈部、双侧锁骨上、双侧腋窝及双侧腹股沟浅表淋巴结。所有区域均发现多个淋巴结肿大。右侧腮腺和右后颈部区域也分别发现许多实性结节。左侧胸壁可见大量实性结节。实验室检查显示全血嗜酸性粒细胞百分比为39.40%，总免疫球蛋白E（IgE）水平>5000 kU/L，血清针对Phadiatop（吸入性变应原）和fx5（食物变应原）的特异性IgE分别为1.01和1.04 kUA/L。经过全面检查后，直接切除了位于右侧颈部、耳后和左侧腋窝区域以及左侧胸壁的肿块。术后病理结果显示为木村病。
本研究讨论的病例极为罕见，不符合木村病常见的受累部位和年龄特征。此病例表现可用于提高医生对该疾病的认识。
