Department of Genetics, University of Wisconsin-Madison, 3476 Genetics and Biotechnology, 425 Henry Mall, Madison, Wisconsin 53706, USA.
Nat Rev Neurosci. 2010 Aug;11(8):577-88. doi: 10.1038/nrn2881.
There has been considerable progress in elucidating the molecular mechanisms that contribute to memory formation and the generation of circadian rhythms. However, it is not well understood how these two processes interact to generate long-term memory. Recent studies in both vertebrate and invertebrate models have shown time-of-day effects on neurophysiology and memory formation, and have revealed a possible role for cycling molecules in memory persistence. Together, these studies suggest that common mechanisms underlie circadian rhythmicity and long-term memory formation.
在阐明有助于记忆形成和昼夜节律产生的分子机制方面已经取得了相当大的进展。然而,人们尚不清楚这两个过程如何相互作用以产生长期记忆。最近在脊椎动物和无脊椎动物模型中的研究表明,昼夜节律对神经生理学和记忆形成有影响,并揭示了循环分子在记忆持久性中的可能作用。这些研究共同表明,昼夜节律和长期记忆形成的背后存在共同的机制。