Health Sciences Center, Winnipeg, MB, Canada.
Lancet Neurol. 2010 Aug;9(8):820-8. doi: 10.1016/S1474-4422(10)70135-6.
Although the interaction between comorbidities and chronic diseases is strong, the effect of comorbidities receives little attention in many chronic diseases. In multiple sclerosis (MS), an increasing amount of evidence suggests that physical and mental comorbidities, and adverse health factors such as smoking and obesity, are common and can affect the disease. These comorbid diseases and lifestyle factors affect clinical phenotype, the diagnostic delay between symptom onset and diagnosis, disability progression, and health-related quality of life. Future studies of comorbidity and MS should consider comorbidities and health behaviours and should take into account the modifying effects of socioeconomic status, ethnic origin, and cultural factors. Studies of the frequency of comorbidities in patients with MS should be population based, incorporating appropriate comparator groups. These studies should expand the range of comorbidities assessed, and examine how the frequency of comorbidities is changing over time. Further research is needed to answer many other questions about comorbidities and their associations with MS, including the best way to measure and analyse comorbidities to understand these associations.
虽然合并症与慢性病之间存在很强的相互作用，但在许多慢性病中，合并症的影响却很少受到关注。在多发性硬化症（MS）中，越来越多的证据表明，身体和精神合并症以及吸烟和肥胖等不良健康因素很常见，并且会影响疾病。这些合并疾病和生活方式因素会影响临床表型、症状出现与诊断之间的诊断延迟、残疾进展和与健康相关的生活质量。未来对合并症与 MS 的研究应考虑合并症和健康行为，并应考虑社会经济地位、种族起源和文化因素的调节作用。MS 患者合并症频率的研究应该基于人群，纳入适当的对照组。这些研究应扩大评估合并症的范围，并研究合并症的频率随时间变化的情况。需要进一步研究来回答有关合并症及其与 MS 关联的许多其他问题，包括衡量和分析合并症以了解这些关联的最佳方法。
