20 世纪至 21 世纪期间流感引发的帕金森病及神经学表现。
Parkinsonism and neurological manifestations of influenza throughout the 20th and 21st centuries.
机构信息
University of Florida Movement Disorders Center, Department of Neurology, Gainesville, FL, USA.
出版信息
Parkinsonism Relat Disord. 2010 Nov;16(9):566-71. doi: 10.1016/j.parkreldis.2010.06.012. Epub 2010 Jul 21.
PURPOSE
Given the recent paper by Jang et al. on "A Highly Pathogenic H5N1 Influenza Virus" which reported a novel animal model of parkinsonism, we aimed to perform a complete historical review of the 20th and 21st century literature on parkinsonism and neurological manifestations of influenza.
SCOPE
There were at least twelve major flu pandemics reported in the literature in the 20th and 21st century. Neurological manifestations most prevalent during the pandemics included delirium, encephalitis, ocular abnormalities, amyotrophy, myelopathy, radiculopathy, ataxia and seizures. Very little parkinsonism was reported with the exception of the 1917 cases originally described by von Economo.
CONCLUSIONS
To date there have been surprisingly few cases of neurological issues inclusive of parkinsonism associated with influenza pandemics. Given the recent animal model of H5N1 influenza associated parkinsonism, the medical establishment should be prepared to evaluate for the re-emergence of parkinsonism during future outbreaks.
目的
鉴于最近 Jang 等人发表的关于“高致病性 H5N1 流感病毒”的论文报告了一种新型帕金森病动物模型，我们旨在对 20 世纪和 21 世纪有关帕金森病和流感神经表现的文献进行全面的历史回顾。
范围
在 20 世纪和 21 世纪的文献中，至少有十二次重大流感大流行被报道。大流行期间最常见的神经系统表现包括意识障碍、脑炎、眼部异常、肌萎缩、脊髓病、神经根病、共济失调和癫痫。除了 von Economo 最初描述的 1917 年病例外，很少有帕金森病的报道。
结论
迄今为止，与流感大流行相关的神经系统问题（包括帕金森病）的病例出人意料地少。鉴于最近 H5N1 流感与帕金森病相关的动物模型，医疗保健机构应该准备好在未来的疫情爆发期间评估帕金森病的再次出现。
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