Holzman P S, O'Brian C, Waternaux C
Harvard University, Department of Psychology, Cambridge, MA 02138.
Biol Psychiatry. 1991 May 15;29(10):1001-15. doi: 10.1016/0006-3223(91)90357-r.
Smooth pursuit eye movements (SPEMs) of 11 bipolar manic patients were impaired during lithium treatment, which, however, improved their clinical condition. SPEM impairment was evident in a general qualitative degradation of eye tracking integrity, in a tendency for gain to be lowered, and in an increase in the number of saccadic events. Individual differences in the nature and magnitude of effects of lithium on eye movements were noteworthy.
11 名双相情感障碍躁狂患者在锂盐治疗期间平滑追踪眼动（SPEMs）受损，然而，这却改善了他们的临床状况。SPEM 受损表现为眼动追踪完整性普遍质性下降、增益有降低趋势以及扫视事件数量增加。锂盐对眼动影响的性质和程度存在个体差异，这一点值得注意。
