Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany.
Nature. 2010 Jul 22;466(7305):E1. doi: 10.1038/nature09255.
During mitosis in Saccharomyces cerevisiae, senescence factors such as extrachromosomal ribosomal DNA circles (ERCs) are retained in the mother cell and excluded from the bud/daughter cell. Shcheprova et al. proposed a model suggesting segregation of ERCs through their association with nuclear pore complexes (NPCs) and retention of pre-existing NPCs in the mother cell during mitosis. However, this model is inconsistent with previous data and we demonstrate here that NPCs do efficiently migrate from the mother into the bud. Therefore, binding to NPCs does not seem to explain the retention of ERCs in the mother cell.
在酿酒酵母的有丝分裂过程中，衰老因子，如染色体外核糖体 DNA 环 (ERC)，会保留在母细胞中，并从芽/子细胞中排除。Shcheprova 等人提出了一个模型，该模型表明 ERC 通过与核孔复合物 (NPC) 结合并在有丝分裂过程中保留母细胞中原有的 NPC 进行分离。然而，这个模型与以前的数据不一致，我们在这里证明 NPC 确实能够从母细胞有效地迁移到芽细胞中。因此，与 NPC 的结合似乎并不能解释 ERC 在母细胞中的保留。
