Zhang X
Department of Pathology, PUMC Hospital, Beijing.
Zhonghua Bing Li Xue Za Zhi. 1991 Mar;20(1):47-9.
23 cases of nonfunctional pituitary adenoma were studied with light and electron microscopy as well as with immunohistochemical stains PAP technique. Under routine light microscopy, 17 cases were chromophobic adenomas; anyhow, electron microscopy showed that there were 6 cases of oncocytoma; 7 cases of undifferentiated cell adenoma; 4 cases of gonadotropic adenoma; 4 cases of mixed adenomas 1 cases of sparsely granulated GH cell adenoma and 1 case of sparsely granulated PRL cell adenoma. Immunohistochemical stain showed: null cell adenomas 7 cases, FSH cell adenoma 3 cases, LH cell adenoma 1 case, GH cell adenoma 2 cases and other mixed adenoma 10 cases. Therefore, the nonfunctional pituitary adenoma is actually a mixture, and the null cell adenoma was only about 1/3 in this series. Among them, most of the hormones gave no function expression themselves.
对23例无功能性垂体腺瘤进行了光镜、电镜及免疫组织化学PAP技术研究。常规光镜下，17例为嫌色性腺瘤；但电镜显示，有6例嗜酸细胞瘤；7例未分化细胞腺瘤；4例促性腺激素腺瘤；4例混合性腺瘤，1例颗粒稀疏的生长激素细胞腺瘤和1例颗粒稀疏的催乳素细胞腺瘤。免疫组织化学染色显示：无功能细胞腺瘤7例，卵泡刺激素细胞腺瘤3例，黄体生成素细胞腺瘤1例，生长激素细胞腺瘤2例，其他混合性腺瘤10例。因此，无功能性垂体腺瘤实际上是一种混合体，在本系列中无功能细胞腺瘤仅约占1/3。其中，大多数激素本身无功能表达。
