Hassoun J, Charpin C, Jaquet P, Lissitzky J C, Grisoli F, Toga M
Arch Pathol Lab Med. 1982 Jan;106(1):25-30.
Twenty silent human pituitary adenomas were morphologically studied. Immunoperoxidase methods showed numerous adrenocorticotropic hormone-immunoreactive tumor cells in 14 cases by light microscopy and in one additional case by electron microscopy. Three of these cases were positive for beta-endorphin and one for beta-lipotropin by electron microscopy. These immunoreactions were found in undifferentiated tumors as well as in oncocytic adenomas, and could not be related to the presence of basophils by light microscopy. The peptides so detected in silent adenomas may have no biological activity and may correspond to common precursor molecule subunits.
对20例无功能性垂体腺瘤进行了形态学研究。免疫过氧化物酶法显示，14例在光镜下有大量促肾上腺皮质激素免疫反应性肿瘤细胞，1例在电镜下也有此发现。其中3例电镜下β-内啡肽呈阳性，1例β-促脂素呈阳性。这些免疫反应在未分化肿瘤及嗜酸性细胞瘤中均有发现，光镜下与嗜碱性细胞的存在无关。在无功能性腺瘤中检测到的这些肽可能无生物活性，可能对应于常见前体分子亚基。
