Hein G, Abendroth K, Müller A, Wessel G
Department of Internal Medicine, Friedrich Schiller University, Jena, Germany.
Clin Rheumatol. 1991 Mar;10(1):13-7. doi: 10.1007/BF02208026.
To demonstrate an as yet merely postulated generalized osteopathy in psoriatics, the serum calcium level, the alkaline phosphatase in the serum and the urinary excretion of hydroxyproline were evaluated in 24 patients with Ps and 24 patients with PA. Moreover, the bone bioptates from 25 patients with PA and 10 patients with Ps were examined histologically and measured morphometrically. The investigations provide evidence for the existence of a generalized "latent" osteopathy in terms of an elevated bone turnover rate without loss of bone volume (high turnover remodelling) in both patients with PA as well as those with Ps without arthritis. As a pathogenetically essential factor shared by dermatosis and "osteopathy", latent vitamin D deficiency and/or D hormone resistance is discussed.
为了证实银屑病患者中一种尚未得到证实的全身性骨病，我们对24例银屑病患者和24例银屑病关节炎患者的血清钙水平、血清碱性磷酸酶以及羟脯氨酸的尿排泄量进行了评估。此外，对25例银屑病关节炎患者和10例银屑病患者的骨活检组织进行了组织学检查和形态计量学测量。研究结果表明，在银屑病关节炎患者以及无关节炎的银屑病患者中，均存在全身性“潜伏性”骨病，表现为骨转换率升高但骨量无丢失（高转换重塑）。作为皮肤病和“骨病”共同的发病机制关键因素，潜伏性维生素D缺乏和/或D激素抵抗被提及。
