Mukhopadhyay Swagatam, Nagaraj Vijayalakshmi H, Sengupta Anirvan M
BioMaPS Institute, Rutgers University, Piscataway, NJ 08854, USA.
Biosystems. 2010 Oct;102(1):49-54. doi: 10.1016/j.biosystems.2010.07.012. Epub 2010 Jul 22.
Current biological models of epigenetic switches built on chromatin modifications lead to strong constraints on the repertoire of dynamic behaviors for the system. We use the structure of the bifurcation diagram of the underlying dynamical system to explain the existing single cell data in silencing by the SIR system in yeast.
基于染色质修饰构建的当前表观遗传开关生物学模型对系统动态行为的全部内容产生了强烈限制。我们利用基础动力系统分岔图的结构来解释酵母中SIR系统沉默方面现有的单细胞数据。
