Wang Thomas D
Division of Gastroenterology and Hepatology, Department of Medicine, University of Michigan School of Medicine, 109 Zina Pitcher Place, BSRB 1522, Ann Arbor, MI 48109, USA.
Gastrointest Endosc Clin N Am. 2010 Jul;20(3):579-83. doi: 10.1016/j.giec.2010.03.013.
Molecular imaging is a rapidly growing new discipline in gastrointestinal endoscopy that involves the development of novel imaging probes and instruments to visualize the molecular expression pattern of mucosa in the digestive tract. Several platforms for imaging agents, including antibody and peptide, are being developed to target over expressed biomolecules in cancer. In addition, novel imaging instruments, including fluorescence endoscopy and confocal microscopy, are being developed to provide wide-area surveillance and microscopic examination, respectively. These methods are being applied to detect the presence of flat and depressed colonic neoplasms and to identify tumor margins.
分子成像技术是胃肠内镜领域中一门迅速发展的新学科，它涉及新型成像探针和仪器的研发，用于可视化消化道黏膜的分子表达模式。目前正在开发多种成像剂平台，包括抗体和肽类，以靶向癌症中过度表达的生物分子。此外，新型成像仪器，如荧光内镜和共聚焦显微镜，也正在分别开发用于提供广域监测和微观检查。这些方法正被应用于检测扁平型和凹陷型结肠肿瘤的存在，并确定肿瘤边界。
