Aldrich Melissa B, Marshall Milton V, Sevick-Muraca Eva M, Lanza Greg, Kotyk John, Culver Joseph, Wang Lihong V, Uddin Jashim, Crews Brenda C, Marnett Lawrence J, Liao Joseph C, Contag Chris, Crawford James M, Wang Ken, Reisdorph Bill, Appelman Henry, Turgeon D Kim, Meyer Charles, Wang Tom
Biomed Opt Express. 2012 Apr 1;3(4):764-76. doi: 10.1364/BOE.3.000764. Epub 2012 Mar 22.
Medical imaging is an invaluable tool for diagnosis, surgical guidance, and assessment of treatment efficacy. The Network for Translational Research (NTR) for Optical Imaging consists of four research groups working to "bridge the gap" between lab discovery and clinical use of fluorescence- and photoacoustic-based imaging devices used with imaging biomarkers. While the groups are using different modalities, all the groups face similar challenges when attempting to validate these systems for FDA approval and, ultimately, clinical use. Validation steps taken, as well as future needs, are described here. The group hopes to provide translational validation guidance for itself, as well as other researchers.
医学成像是用于诊断、手术引导和治疗效果评估的一项宝贵工具。光学成像转化研究网络（NTR）由四个研究小组组成，致力于在实验室发现与基于荧光和光声成像设备的成像生物标志物的临床应用之间“架起桥梁”。虽然这些小组使用不同的成像方式，但在试图为FDA批准以及最终临床应用验证这些系统时，所有小组都面临类似的挑战。本文描述了已采取的验证步骤以及未来需求。该小组希望为自身以及其他研究人员提供转化验证指导。
