Chauhan B L, Kulkarni R D
R and D Centre, Himalaya Drug Co., Bombay, India.
Eur J Clin Pharmacol. 1991;40(2):189-91. doi: 10.1007/BF00280076.
In 8 social drinkers, the effect of a single dose of Liv.52 or placebo on ethanol absorption has been studied after ingestion of 30 ml whisky in 5 min. The t1/2 absorption with Liv.52 was 3.62 min, significantly less than after placebo, 6.29 min. The peak concentration after Liv.52 (49.9 mg.100 ml-1) was significantly higher than with placebo (40.5 mg.100 ml-1). Whisky 120 ml consumed by regular alcohol users in 1 h, before and following 15 days of Liv.52 treatment produced significantly higher ethanol levels at 2, 3 and 4 h and significantly lower acetaldehyde levels at 3 and 4 h after Liv.52 treatment. Liv.52 enhanced the rate of absorption of ethanol and rapidly reduced acetaldehyde levels, which may explain its hepatoprotective effect on ethanol-induced liver damage.
在8名社交饮酒者中，研究了单次服用利肝宝（Liv.52）或安慰剂对5分钟内摄入30毫升威士忌后乙醇吸收的影响。服用利肝宝后的吸收半衰期（t1/2）为3.62分钟，显著短于服用安慰剂后的6.29分钟。服用利肝宝后的峰值浓度（49.9毫克/100毫升）显著高于服用安慰剂后的（40.5毫克/100毫升）。经常饮酒者在利肝宝治疗15天前后，1小时内饮用120毫升威士忌，利肝宝治疗后2、3和4小时的乙醇水平显著升高，3和4小时的乙醛水平显著降低。利肝宝提高了乙醇的吸收速率并迅速降低了乙醛水平，这可能解释了其对乙醇诱导的肝损伤的保肝作用。
