Holtzman J L, Gebhard R L, Eckfeldt J H, Mottonen L R, Finley D K, Eshelman F N
Clin Pharmacol Ther. 1985 Aug;38(2):157-63. doi: 10.1038/clpt.1985.152.
We examined in normal men and women the effects of chronic ethanol consumption and the coadministration of cimetidine and ranitidine on the kinetics of ethanol. We found that the consumption of 45 gm ethanol per day for 3 weeks increased the apparent volume of distribution of ethanol in men from 732 to 884 ml/kg (P less than 0.01) but had no such effect in women (697 ml/kg before ethanol and 746 ml/kg after chronic ethanol consumption). This combined therapy had no effect on the rate of ethanol disappearance in either sex. In men the rate of disappearance was 165 mg/L/hr before and 168 mg/L/hr after chronic consumption, while in women the respective values were 209 and 203 mg/L/hr. The addition of either cimetidine or ranitidine had no effect on either parameter compared with values observed on day 22 of the study. In view of the known inhibitory effects of cimetidine on cytochrome P-450-dependent enzymes, our data suggest that this enzyme system does not metabolize a significant fraction of ingested ethanol in subjects who have consumed moderate doses of alcohol for several weeks.
我们研究了长期饮用乙醇以及同时服用西咪替丁和雷尼替丁对正常男性和女性体内乙醇动力学的影响。我们发现，男性每天饮用45克乙醇，持续3周后，乙醇的表观分布容积从732毫升/千克增加到884毫升/千克（P<0.01），但女性没有这种影响（饮用乙醇前为697毫升/千克，长期饮用乙醇后为746毫升/千克）。这种联合疗法对两性乙醇的消除速率均无影响。男性长期饮用乙醇前的消除速率为165毫克/升/小时，饮用后为168毫克/升/小时，而女性相应的值分别为209和203毫克/升/小时。与研究第22天观察到的值相比，添加西咪替丁或雷尼替丁对任何一个参数均无影响。鉴于已知西咪替丁对细胞色素P-450依赖性酶有抑制作用，我们的数据表明，在连续几周摄入适量酒精的受试者中，该酶系统对摄入乙醇的代谢作用不显著。
