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海洋来源内生真菌 Penicillium commune G2M 的化学成分研究

Chemical constituents of a marine-derived endophytic fungus Penicillium commune G2M.

机构信息

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.

出版信息

Molecules. 2010 May 4;15(5):3270-5. doi: 10.3390/molecules15053270.

DOI:10.3390/molecules15053270
PMID:20657476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6257498/
Abstract

Cultivation of the endophytic fungus Penicillium commune, which was isolated from the semi-mangrove plant Hibiscus tiliaceus, afforded one new compound 1-O-(2,4-dihydroxy-6-methylbenzoyl)-glycerol (1) along with thirteen known products, including 1-O-acetylglycerol (2), N-acetyltryptophan (3), 3-indolylacetic acid methyl ester (4), 1-(2,4-dihydroxy-3,5-dimethylphenyl)ethanone (5), 2-(2,5-dihydroxyphenyl)acetic acid (6), (4R,5S)-5-hydroxyhexan-4-olide (7), thymidine (8), uracil (9), thymine (10), ergosterol (11), beta-sitosterol (12),beta-daucosterol (13), and ergosta-7,22-dien-3beta,5 alpha,6 beta-triol (14). The structures of these compounds were established by detailed NMR spectroscopic analysis, as well as by comparison with literature data or with authentic samples.

摘要

从半红树林植物黄槿中分离得到的内生真菌青霉共培养,得到了一种新化合物 1-O-(2,4-二羟基-6-甲基苯甲酰基)-甘油(1),以及 13 种已知产物,包括 1-O-乙酰基甘油(2)、N-乙酰色氨酸(3)、3-吲哚基乙酸甲酯(4)、1-(2,4-二羟基-3,5-二甲基苯基)乙酮(5)、2-(2,5-二羟基苯基)乙酸(6)、(4R,5S)-5-羟基己烷-4-内酯(7)、胸苷(8)、尿嘧啶(9)、胸腺嘧啶(10)、麦角甾醇(11)、β-谷甾醇(12)、β-达玛甾醇(13)和麦角甾-7,22-二烯-3β,5α,6β-三醇(14)。这些化合物的结构通过详细的 NMR 光谱分析以及与文献数据或标准样品的比较确定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea73/6257498/201c5b8ad2e9/molecules-15-03270-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea73/6257498/201c5b8ad2e9/molecules-15-03270-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea73/6257498/201c5b8ad2e9/molecules-15-03270-g001.jpg

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