Dipartimento di Produzione Vegetale, Università degli Studi di Milano, Milano, Italy.
Molecules. 2010 May 14;15(5):3517-55. doi: 10.3390/molecules15053517.
Plant secondary metabolites include an array of bioactive constituents form both medicinal and food plants able to improve human health. The exposure to these phytochemicals, including phenylpropanoids, isoprenoids and alkaloids, through correct dietary habits, may promote health benefits, protecting against the chronic degenerative disorders mainly seen in Western industrialized countries, such as cancer, cardiovascular and neurodegenerative diseases. In this review, we briefly deal with some plant foods and herbs of traditional medicines and diets, focusing on their neuroprotective active components. Because oxidative stress and neuroinflammation resulting from neuroglial activation, at the level of neurons, microglial cells and astrocytes, are key factors in the etiopathogenesis of both neurodegenerative and neurological diseases, emphasis will be placed on the antioxidant and anti-inflammatory activity exerted by specific molecules present in food plants or in remedies prescribed by herbal medicines.
植物次生代谢物包括一系列具有生物活性的成分,来自药用和食用植物,能够改善人类健康。通过正确的饮食习惯摄入这些植物化学物质,包括苯丙烷类、类异戊二烯类和生物碱类,可以促进健康益处,预防主要见于西方国家的慢性退行性疾病,如癌症、心血管疾病和神经退行性疾病。在这篇综述中,我们简要介绍了一些传统药物和饮食中的植物性食物和草药,重点介绍了它们的神经保护活性成分。因为神经胶质细胞激活导致的氧化应激和神经炎症,在神经元、小胶质细胞和星形胶质细胞水平上,是神经退行性和神经疾病发病机制中的关键因素,因此将重点放在食物植物或草药中特定分子的抗氧化和抗炎活性上。