用于生物医学成像与传感的共光路光学相干断层扫描技术
Common-Path Optical Coherence Tomography for Biomedical Imaging and Sensing.
作者信息
Kang Jin U, Han Jae-Ho, Liu Xuan, Zhang Kang
机构信息
Department of Electrical and Computer Engineering, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.
出版信息
J Opt Soc Korea. 2010 Mar;14(1):1-13. doi: 10.3807/JOSK.2010.14.1.001.
This paper describes a development of a fiber optic common-path optical coherence tomography (OCT) based imaging and guided system that possess ability to reliably identify optically transparent targets that are on the micron scale; ability to maintain a precise and safe position from the target; ability to provide spectroscopic imaging; ability to imaging biological target in 3-D. The system is based on a high resolution fiber optic Common-Path OCT (CP-OCT) that can be integrated into various mini-probes and tools. The system is capable of obtaining >70K A-scan per second with a resolution better than 3 μm. We have demonstrated that the system is capable of one-dimensional real-time depth tracking, tool motion limiting and motion compensation, oxygen-saturation level imaging, and high resolution 3-D images for various biomedical applications.
本文描述了一种基于光纤共光路光学相干断层扫描（OCT）的成像与引导系统的开发，该系统具备可靠识别微米级光学透明目标的能力；与目标保持精确且安全距离的能力；提供光谱成像的能力；对生物目标进行三维成像的能力。该系统基于高分辨率光纤共光路OCT（CP - OCT），可集成到各种微型探头和工具中。该系统能够以每秒超过70K次的A扫描获取数据，分辨率优于3μm。我们已经证明，该系统能够进行一维实时深度跟踪、工具运动限制和运动补偿、血氧饱和度水平成像，以及用于各种生物医学应用的高分辨率三维图像。
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