Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
Braz J Med Biol Res. 2010 Aug;43(8):777-85. doi: 10.1590/s0100-879x2010007500069. Epub 2010 Jul 23.
The purpose of this study was to determine the middle latency response (MLR) characteristics (latency and amplitude) in children with (central) auditory processing disorder [(C)APD], categorized as such by their performance on the central auditory test battery, and the effects of these characteristics after auditory training. Thirty children with (C)APD, 8 to 14 years of age, were tested using the MLR-evoked potential. This group was then enrolled in an 8-week auditory training program and then retested at the completion of the program. A control group of 22 children without (C)APD, composed of relatives and acquaintances of those involved in the research, underwent the same testing at equal time intervals, but were not enrolled in the auditory training program. Before auditory training, MLR results for the (C)APD group exhibited lower C3-A1 and C3-A2 wave amplitudes in comparison to the control group [C3-A1, 0.84 microV (mean), 0.39 (SD--standard deviation) for the (C)APD group and 1.18 microV (mean), 0.65 (SD) for the control group; C3-A2, 0.69 microV (mean), 0.31 (SD) for the (C)APD group and 1.00 microV (mean), 0.46 (SD) for the control group]. After training, the MLR C3-A1 [1.59 microV (mean), 0.82 (SD)] and C3-A2 [1.24 microV (mean), 0.73 (SD)] wave amplitudes of the (C)APD group significantly increased, so that there was no longer a significant difference in MLR amplitude between (C)APD and control groups. These findings suggest progress in the use of electrophysiological measurements for the diagnosis and treatment of (C)APD.
本研究旨在确定具有（中枢）听觉处理障碍（APD）的儿童（即根据他们在中枢听觉测试中的表现进行分类）的中潜伏期反应（MLR）特征（潜伏期和幅度），以及这些特征在听觉训练后的变化。30 名年龄在 8 至 14 岁之间的 APD 儿童接受了 MLR 诱发电位测试。然后，该组参加了为期 8 周的听觉训练计划，并在计划完成后进行了重新测试。一个由无 APD 的 22 名儿童组成的对照组，由参与研究的亲属和熟人组成，在相等的时间间隔内接受了相同的测试，但没有参加听觉训练计划。在听觉训练之前，与对照组相比，APD 组的 MLR 结果显示 C3-A1 和 C3-A2 波幅度较低[C3-A1，0.84 微伏（均值），0.39（SD-标准差）APD 组和 1.18 微伏（均值），0.65（SD）对照组；C3-A2，0.69 微伏（均值），0.31（SD）APD 组和 1.00 微伏（均值），0.46（SD）对照组]。训练后，APD 组的 MLR C3-A1[1.59 微伏（均值），0.82（SD）]和 C3-A2[1.24 微伏（均值），0.73（SD）]波幅度显著增加，因此 MLR 幅度在 APD 和对照组之间不再有显著差异。这些发现表明，电生理测量在 APD 的诊断和治疗中的应用取得了进展。
