Natural Sciences and Science Education, National Institute of Education, Singapore.
Biofouling. 2010 Aug;26(6):685-95. doi: 10.1080/08927014.2010.508343.
Filamentous benthic marine cyanobacteria are a prolific source of structurally unique bioactive secondary metabolites. A total of 12 secondary metabolites, belonging to the mixed polyketide-polypeptide structural class, were isolated from the marine cyanobacterium, Lyngbya majuscula, and were tested to determine if they showed activity against barnacle larval settlement. The assays revealed four compounds, dolastatin 16, hantupeptin C, majusculamide A, and isomalyngamide A, that showed moderate to potent anti-larval settlement activities, with EC(50) values ranging from 0.003 to 10.6 microg ml(-1). In addition, field testing conducted over a period of 28 days (using the modified Phytagel method) based on the cyanobacterial compound, dolastatin 16, showed significantly reduced barnacle settlement as compared to controls at all the concentrations tested. The results of this study highlight the importance of marine cyanobacteria as an underexplored source of potential environmentally friendly antifoulants.
丝状底栖海洋蓝藻是结构独特的生物活性次生代谢产物的丰富来源。从海洋蓝藻 Lyngbya majuscula 中分离出了 12 种次生代谢产物，属于混合聚酮-多肽结构类别，并对其进行了测试，以确定它们是否对藤壶幼虫附着具有活性。这些测定结果显示，有 4 种化合物（海兔肽 16、汉图肽 C、大柳珊瑚胺 A 和异马兰胺 A）具有中度至强的抗幼虫附着活性，EC（50）值范围为 0.003 至 10.6μg/ml。此外，基于蓝藻化合物海兔肽 16 进行的为期 28 天的现场测试（使用改良的 Phytagel 方法）表明，与对照组相比，在所有测试浓度下，藤壶的附着率都显著降低。这项研究的结果强调了海洋蓝藻作为潜在环保型防污剂的未充分开发来源的重要性。
