Sitachitta N, Gerwick W H
College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA.
J Nat Prod. 1998 May;61(5):681-4. doi: 10.1021/np970576a.
Grenadadiene (1), debromogrenadiene (2), and grenadamide (3), three structurally unique cyclopropyl-containing metabolites, were isolated from the organic extract of a Grenada collection of the marine cyanobacterium Lyngbya majuscula. The structures and the relative stereochemistries of these compounds were determined using spectroscopic methods. These are the first reported cyclopropyl-containing fatty acid derivatives from a Lyngbya sp. Grenadadiene (1) has an interesting profile of cytotoxicity in the NCI 60 cell line assay, while grenadamide (2) exhibited modest brine shrimp toxicity (LD50 = 5 microg/mL) and cannabinoid receptor binding activity (Ki = 4.7 microM).
从格林纳达采集的海洋蓝藻巨大鞘丝藻（Lyngbya majuscula）的有机提取物中分离出了三种结构独特的含环丙基代谢产物，即格氏二烯（1）、脱溴格氏二烯（2）和格氏酰胺（3）。使用光谱方法确定了这些化合物的结构和相对立体化学。这些是首次报道的来自鞘丝藻属（Lyngbya sp.）的含环丙基脂肪酸衍生物。格氏二烯（1）在NCI 60细胞系试验中具有有趣的细胞毒性特征，而格氏酰胺（2）表现出适度的卤虫毒性（LD50 = 5微克/毫升）和大麻素受体结合活性（Ki = 4.7微摩尔）。
