Psychogeriatric Clinic, Laboratory of Neuroscience (LIM 27), Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
Int J Geriatr Psychiatry. 2011 Apr;26(4):403-8. doi: 10.1002/gps.2540.
To identify the CAMCOG sub-items that best contribute for the identification of patients with mild cognitive impairment (MCI) and incipient Alzheimer's disease (AD) in clinical practice.
Cross-sectional assessment of 272 older adults (98 MCI, 82 AD, and 92 controls) with a standardized neuropsychological battery and the CAMCOG schedule. Backward logistic regression analysis with diagnosis (MCI and controls) as dependent variable and the sub-items of the CAMCOG as independent variable was carried out to determine the CAMCOG sub-items that predicted the diagnosis of MCI.
Lower scores on Language, Memory, Praxis, and Calculation CAMCOG sub-items were significantly associated with the diagnosis of MCI. A composite score obtained by the sum of these scores significantly discriminated MCI patients from comparison groups. This reduced version of the CAMCOG showed similar diagnostic accuracy than the original schedule for the identification of patients with MCI as compared to controls (AUC = 0.80 ± 0.03 for the reduced CAMCOG; AUC = 0.79 ± 0.03 for the original CAMCOG).
This reduced version of the CAMCOG had similar diagnostic properties as the original CAMCOG and was faster and easier to administer, rendering it more suitable for the screening of subtle cognitive deficits in general clinical practice.
确定 CAMCOG 子项，以帮助临床医生识别轻度认知障碍（MCI）和早期阿尔茨海默病（AD）患者。
对 272 名老年人（98 名 MCI、82 名 AD 和 92 名对照者）进行横断面评估，使用标准化神经心理学测试和 CAMCOG 量表。以诊断（MCI 和对照组）为因变量，CAMCOG 子项为自变量，进行向后逻辑回归分析，以确定预测 MCI 诊断的 CAMCOG 子项。
CAMCOG 量表中的语言、记忆、实践和计算子项得分较低与 MCI 的诊断显著相关。这些得分的总和构成的综合得分可显著区分 MCI 患者与对照组。与原始 CAMCOG 相比，该简化版 CAMCOG 对 MCI 患者与对照组的识别具有相似的诊断准确性（简化版 CAMCOG 的 AUC 为 0.80±0.03，原始版 CAMCOG 的 AUC 为 0.79±0.03）。
该简化版 CAMCOG 具有与原始版 CAMCOG 相似的诊断特性，且更快速、更易于实施，使其更适用于一般临床实践中对细微认知缺陷的筛查。
