College of Animal Sciences, Zhejiang University, 268 Kai-Xuan Road, Hangzhou 310029, P R China.
Chem Biodivers. 2010 Jan;7(1):158-67. doi: 10.1002/cbdv.200800324.
Two new disulfated triterpene glycosides, pentactasides B and C (1 and 2, resp.), were isolated from the sea cucumber Pentacta quadrangularis collected from the South China Sea. Their structures were elucidated by extensive spectral analysis (2D-NMR and MS) and chemical methods. The compounds 1 and 2 possess the same tetrasaccharide moieties with two sulfated groups, but are different in the side chains of the triterpene aglycone. Pentactasides B and C (1 and 2, resp.) showed significant cytotoxicities (IC(50) 0.09-2.30 microM) against different human tumor cell lines.
从南海采集的四角星盘海参中分离得到两种新的二硫酸化三萜糖苷，分别为戊糖五甙 B 和 C（1 和 2）。通过广泛的光谱分析（2D-NMR 和 MS）和化学方法阐明了它们的结构。化合物 1 和 2 具有相同的四糖部分，带有两个硫酸基团，但三萜苷元的侧链不同。戊糖五甙 B 和 C（1 和 2）对不同的人肿瘤细胞系显示出显著的细胞毒性（IC500.09-2.30μM）。
