Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
Planta Med. 2009 Dec;75(15):1608-12. doi: 10.1055/s-0029-1185865.
Two new triterpene glycosides, scabraside A (1) and B (2), and a structurally known compound (3), were isolated from the sea cucumber Holothuria scabra (Holothuriidae) collected from the South China Sea. Structure of these compounds was elucidated by spectroscopic and chemical methods. The glycosides 1 and 2 exhibit the same common structural features, i. e., the presence of 12- and 17-hydroxy groups in the holostane-type triterpene aglycone with a 9(11)-ene bond, but are different in the side chains of the triterpene aglycone. The glycosides 1 and 2 had significant in vitro cytotoxicity against four human tumor cell lines in comparison to 10-hydroxycamptothecin.
从南海采集的糙海参（Holothuriidae）中分离得到两种新的三萜糖苷，分别为糙海参苷 A（1）和 B（2），以及一种结构已知的化合物（3）。通过光谱和化学方法阐明了这些化合物的结构。糖苷 1 和 2 具有相同的共同结构特征，即 12-和 17-羟基存在于具有 9(11)-烯键的霍氏烷型三萜苷元中，但三萜苷元的侧链不同。糖苷 1 和 2 对四种人肿瘤细胞系的体外细胞毒性明显高于 10-羟基喜树碱。
