胱抑素超家族的朋友与亲属——新成员及其进化
Friends and relations of the cystatin superfamily--new members and their evolution.
作者信息
Brown W M, Dziegielewska K M
机构信息
Department of Anatomy and Physiology, University of Tasmania, Hobart, Australia.
出版信息
Protein Sci. 1997 Jan;6(1):5-12. doi: 10.1002/pro.5560060102.
Abstract
The cystatin "superfamily" encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. In recent years, several new members of the superfamily have characterized, including proteins from insects and plants. Based on partial amino acid homology, new members, such as the invariant chain (Ii), and the transforming growth factor-beta receptor type II (TGF-beta receptor II) may, in fact, represent members of an emerging family within the superfamily that may have used some common building blocks to form functionally diverse proteins. Cystatin super-family members have been found throughout evolution and members of each family of the superfamily are present in mammals today. In this review, the new and older, established members of the family are arranged into a possible evolutionary order, based on sequence homology and functional similarities.
摘要
胱抑素“超家族”包含含有多个胱抑素样序列的蛋白质。其中一些成员是活性半胱氨酸蛋白酶抑制剂，而其他成员则已丧失或可能从未获得这种抑制活性。近年来，该超家族的几个新成员已得到鉴定，包括来自昆虫和植物的蛋白质。基于部分氨基酸同源性，新成员，如不变链（Ii）和转化生长因子-β II型受体（TGF-β受体II），实际上可能代表超家族中一个新兴家族的成员，该家族可能使用了一些共同的构建模块来形成功能多样的蛋白质。胱抑素超家族成员在整个进化过程中都有发现，如今超家族各家族的成员在哺乳动物中均有存在。在本综述中，基于序列同源性和功能相似性，将该家族新的和较老的、已确定的成员排列成一种可能的进化顺序。
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