LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear & Throat Hospital, New York, New York 10022, USA.
Retina. 2010 Sep;30(8):1206-16. doi: 10.1097/IAE.0b013e3181e097f0.
The purpose of this study was to investigate the fundus autofluorescence and optical coherence tomography findings in eyes with acute zonal occult outer retinopathy (AZOOR).
A retrospective observational case series of the fundus autofluorescence and spectral domain optical coherence tomography in a series of patients with AZOOR.
There were 19 eyes of 11 patients (10 women), who had a mean age of 49.1 +/- 13.9 years. Fundus autofluorescence abnormalities were seen in 17 of the 19 eyes, were more common in the peripapillary area, and were smaller in extent than the optical coherence tomography abnormalities. Nine eyes showed progression of hypoautofluorescence area during the mean follow-up of 69.7 months. The mean thickness of the photoreceptor layer at fovea was 177 microm in eyes with AZOOR, which was significantly thinner than controls (193 microm, P = 0.049). Abnormal retinal laminations were found in 12 eyes and were located over areas of loss of the photoreceptors. The subfoveal choroidal thickness was 243 microm, which is normal.
Fundus autofluorescence abnormalities in AZOOR showed distinct patterns of retinal pigment epithelial involvement, which may be progressive. Thinning of photoreceptor cell layer with loss of the outer segments and abnormal inner retinal lamination in the context of a normal choroid are commonly found in AZOOR.
本研究旨在探讨急性区域性隐匿性外层视网膜病变（AZOOR）患者的眼底自发荧光和光相干断层扫描（OCT）的表现。
回顾性观察性病例系列研究，对一系列 AZOOR 患者的眼底自发荧光和频域 OCT 进行分析。
共纳入 11 例（10 名女性）19 只眼，平均年龄为 49.1±13.9 岁。17 只眼（89.5%）的眼底自发荧光存在异常，更常见于视盘周围，范围较 OCT 异常小。9 只眼在平均 69.7 个月的随访中出现了低自发荧光区域的进展。AZOOR 患眼的中心凹处光感受器层平均厚度为 177μm，显著薄于对照组（193μm，P=0.049）。12 只眼存在视网膜分层异常，位于光感受器丧失区域。中心凹下脉络膜厚度为 243μm，正常。
AZOOR 的眼底自发荧光异常显示出明显的视网膜色素上皮受累模式，可能是进行性的。在外层视网膜节段丢失和正常脉络膜背景下的光感受器细胞层变薄以及内层视网膜分层异常在 AZOOR 中很常见。
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