Zibrandtsen Nathalie, Munch Inger Christine, Klemp Kristian, Jørgensen Thomas Martini, Sander Birgit, Larsen Michael
Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Denmark.
Acta Ophthalmol. 2008 Dec;86(8):913-6. doi: 10.1111/j.1600-0420.2007.01140.x. Epub 2008 Jun 11.
To assess retinal morphology in acute zonal occult outer retinopathy (AZOOR) without ophthalmoscopically visible fundus changes.
Retrospective case series. Two consecutive patients with bilateral AZOOR with photopsia corresponding to areas of visual field loss and a normal fundus appearance were examined using optical coherence tomography (OCT), automated perimetry and electroretinography (ERG).
Both patients demonstrated photoreceptor atrophy corresponding to partial or complete scotomata with reduced or extinct electroretinographic responses. Attenuation or complete loss of all the segments composing the photoreceptor layer was found by OCT. Full-field ERG revealed affection of the 30 Hz flicker responses and subnormal photopic responses in both patients and subnormal scotopic responses in case 1. Multifocal electroretinography (mERG) revealed localized outer retinal dysfunction. The field loss was more extensive than the area of photoreceptor loss.
Photoreceptor atrophy can be demonstrated in AZOOR without ophthalmoscopically visible fundus lesions.
评估急性区域性隐匿性外层视网膜病变（AZOOR）患者在眼底镜检查未见眼底改变时的视网膜形态。
回顾性病例系列研究。对两名双侧患有AZOOR且有与视野缺损区域相对应的闪光幻觉、眼底外观正常的连续患者，采用光学相干断层扫描（OCT）、自动视野计和视网膜电图（ERG）进行检查。
两名患者均表现出与部分或完全暗点相对应的光感受器萎缩，视网膜电图反应降低或消失。OCT发现构成光感受器层的所有节段均有衰减或完全缺失。全视野ERG显示两名患者的30Hz闪烁反应均受影响，明视觉反应低于正常，病例1的暗视觉反应也低于正常。多焦视网膜电图（mERG）显示局部外层视网膜功能障碍。视野缺损比光感受器丧失区域更广泛。
在眼底镜检查未见眼底病变的AZOOR患者中可证实存在光感受器萎缩。
