Anderson E C, Doughty W J, Anderson J, Baber D
J Hyg (Lond). 1978 Jun;80(3):451-9. doi: 10.1017/s002217240002492x.
Foot-and-mouth disease virus isolates of types O, A and SAT 2, from diseased animals in herds routinely vaccinated twice a year were compared antigenically with the vaccine strains in the complement-fixation, neutralization and radial immunodiffusion tests. It was found that strains which had readily infected vaccinated cattle had R values against the vaccine strain in the complementfixation and radial immunodiffusion tests of 30 or less, while strains causing primary outbreaks with little spread had R values of 30-40. Threefold differences in humoral neutralizing antibody concentration between the field variant and the vaccine strain in sera from vaccinated animals were likely to be significant in terms of protection.
对来自每年常规接种两次疫苗的畜群中患病动物的O型、A型和SAT 2型口蹄疫病毒分离株，在补体结合试验、中和试验和放射免疫扩散试验中与疫苗株进行了抗原性比较。结果发现，容易感染接种牛的毒株在补体结合试验和放射免疫扩散试验中针对疫苗株的R值为30或更低，而引起原发性疫情且传播很少的毒株R值为30 - 40。就保护而言，接种动物血清中野毒株和疫苗株之间的体液中和抗体浓度有三倍差异可能具有显著意义。
