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本文引用的文献

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DNA aneuploidy in congenital melanocytic nevi: suggestive evidence for premalignant changes.先天性黑素细胞痣中的DNA非整倍体：癌前病变的提示性证据。
J Invest Dermatol. 1984 Jun;82(6):569-72. doi: 10.1111/1523-1747.ep12261301.
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Low- and high-risk malignant melanoma--I. Evaluation of clinical and histological prognosticators in 585 cases.低危和高危恶性黑色素瘤——I. 585例临床和组织学预后因素评估
Eur J Cancer Clin Oncol. 1983 Feb;19(2):227-35. doi: 10.1016/0277-5379(83)90421-2.
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Heterogeneity of primary and metastatic human malignant melanoma as detected with monoclonal antibodies in cryostat sections of biopsies.利用单克隆抗体在活检组织的低温切片中检测原发性和转移性人类恶性黑色素瘤的异质性。
Cancer Immunol Immunother. 1983;16(1):53-8. doi: 10.1007/BF00199906.
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HLA-DR antigen expression in primary melanomas of the skin.皮肤原发性黑色素瘤中HLA - DR抗原的表达
J Invest Dermatol. 1984 Mar;82(3):244-7. doi: 10.1111/1523-1747.ep12260181.
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Common human melanoma-associated antigen(s) detected by monoclonal antibodies.通过单克隆抗体检测到的常见人类黑色素瘤相关抗原
Cancer Res. 1980 Jul;40(7):2523-8.
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Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma.厚度、横截面积及浸润深度在皮肤黑色素瘤预后中的作用
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In situ analysis of antigens on malignant and benign cells of the melanocyte lineage. Differential expression of two surface molecules, gp75 and p89.黑色素细胞系恶性和良性细胞抗原的原位分析。两种表面分子gp75和p89的差异表达。
J Exp Med. 1985 Feb 1;161(2):366-77. doi: 10.1084/jem.161.2.366.
8
A tumor-associated antigen expressed in melanoma cells with lower malignant potential.一种在恶性潜能较低的黑色素瘤细胞中表达的肿瘤相关抗原。
Int J Cancer. 1985 Jun 15;35(6):787-91. doi: 10.1002/ijc.2910350615.
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Phenotypic dynamics of tumor progression in human malignant melanoma.人类恶性黑色素瘤肿瘤进展的表型动力学
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10
Discrimination between benign and malignant cells of melanocytic lineage by two novel antigens, a glycoprotein with a molecular weight of 113,000 and a protein with a molecular weight of 76,000.通过两种新型抗原（一种分子量为113,000的糖蛋白和一种分子量为76,000的蛋白质）区分黑素细胞系的良性和恶性细胞。
Cancer Res. 1987 Feb 1;47(3):841-5.

原发性恶性黑色素瘤中肿瘤细胞特征与患者性别的关系。

The relationship between characteristics of the tumor cells and sex of the patients in primary malignant melanomas.

作者信息

Ostmeier H, Schumann J, Otto F, Krieg V, Fuchs B, Biess B, Burg G, Suter L

机构信息

Fachklinik Hornheide, Münster, FRG.

出版信息

J Cancer Res Clin Oncol. 1991;117(4):364-6. doi: 10.1007/BF01630721.

DOI:10.1007/BF01630721
PMID:2066358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12201060/
Abstract

Sex is a well proven prognosticator in primary malignant melanoma. We studied 19 parameters of tumor cells in primary malignant melanoma from 391 patients, the purpose being to determine if melanomas in men and women are alike. Apart from results in thin melanomas, no difference was seen between the sex groups. Thin melanomas showed a significant difference for the melanoma-associated antigen G7-E2 (higher expression in women) and the histocompatibility antigen HLA-DR (higher expression in men). The results suggest that sex-related prognostic differences are due more to host than to tumor characteristics.

摘要

性别是原发性恶性黑色素瘤中已得到充分证实的预后指标。我们研究了391例原发性恶性黑色素瘤患者肿瘤细胞的19项参数，目的是确定男性和女性的黑色素瘤是否相似。除了薄型黑色素瘤的结果外，不同性别组之间未见差异。薄型黑色素瘤在黑色素瘤相关抗原G7-E2（女性表达较高）和组织相容性抗原HLA-DR（男性表达较高）方面存在显著差异。结果表明，与性别相关的预后差异更多地归因于宿主而非肿瘤特征。