黑色素细胞系恶性和良性细胞抗原的原位分析。两种表面分子gp75和p89的差异表达。
In situ analysis of antigens on malignant and benign cells of the melanocyte lineage. Differential expression of two surface molecules, gp75 and p89.
作者信息
Holzmann B, Johnson J P, Kaudewitz P, Riethmüller G
出版信息
J Exp Med. 1985 Feb 1;161(2):366-77. doi: 10.1084/jem.161.2.366.
Abstract
Monoclonal antibodies (mAb) were selected for differential binding to sections of freshly frozen biopsy material of human malignant melanomas and their precursor lesions, the melanocytic nevi. Both melanomas and normal nevi expressed human Ia-like antigens, transferrin receptor and the transferrin-related molecule p97. In contrast, only 1 nevus of 21 tested expressed both glycoprotein gp75, defined by mAb 15.75, and protein p89, defined by mAb P3.58, whereas 12 of 15 melanomas tested expressed both antigens. mAb P3.58 reacted with one additional melanoma and one nevus. The expression of these two molecules therefore appears to be correlated with the appearance of the malignant phenotype of melanocytes.
摘要
选择单克隆抗体（mAb），使其与人恶性黑色素瘤及其前体病变（黑素细胞痣）的新鲜冷冻活检材料切片进行差异结合。黑色素瘤和正常痣均表达人Ia样抗原、转铁蛋白受体和转铁蛋白相关分子p97。相比之下，在检测的21个痣中，只有1个同时表达了由单克隆抗体15.75定义的糖蛋白gp75和由单克隆抗体P3.58定义的蛋白p89，而在检测的15个黑色素瘤中，有12个表达了这两种抗原。单克隆抗体P3.58还与另外1个黑色素瘤和1个痣发生反应。因此，这两种分子的表达似乎与黑素细胞恶性表型的出现相关。
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