Department of Bioengineering, Stanford University, 318 Campus Drive, Stanford, CA 94305, USA.
Biotechnol J. 2010 Jul;5(7):686-94. doi: 10.1002/biot.201000080.
Recent genome-wide screens of host genetic requirements for viral infection have reemphasized the critical role of host metabolism in enabling the production of viral particles. In this review, we highlight the metabolic aspects of viral infection found in these studies, and focus on the opportunities these requirements present for metabolic engineers. In particular, the objectives and approaches that metabolic engineers use are readily comparable to the behaviors exhibited by viruses during infection. As a result, metabolic engineers have a unique perspective that could lead to novel and effective methods to combat viral infection.
最近对宿主遗传要求进行的全基因组筛选，再次强调了宿主代谢在产生病毒颗粒方面的关键作用。在这篇综述中，我们强调了这些研究中发现的病毒感染的代谢方面，并重点介绍了这些要求为代谢工程师提供的机会。特别是，代谢工程师使用的目标和方法与病毒在感染过程中表现出的行为具有很好的可比性。因此，代谢工程师具有独特的视角，可能会导致对抗病毒感染的新的和有效的方法。
