Serviço de Pneumologia, Hospital de Clínicas de Porto Alegre, and Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Travessa Miranda e Castro 70/204, Bairro Santana, Porto Alegre, Rio Grande do Sul, Brazil 90040-280.
Respir Care. 2010 Aug;55(8):1020-5.
To determine the repeatability of the 6-minute walk test (6MWT) in adolescents and adults with cystic fibrosis (CF).
This was a prospective cross-sectional study. We included consecutive patients ages>or=15 years attending an adult CF program. The patients underwent the 6MWT, pulmonary function tests, and clinical evaluation. The second 6MWT was performed following a rest period of 60 min.
Thirty-one patients were included. The mean+/-SD age was 23.5+/-6.7 y, and the mean FEV1 was 61+/-28% of predicted. The mean+/-SD walked distance in the first 6MWT was 583.6+/-68.6 m and in the second 6MWT was 590.0+/-72.2 m. The mean difference between the first and second 6MWT was -6.5 m, with limits of agreement between -74.9 m and 61.9 m, and the coefficient of variation was 4.3%. The mean oxygen desaturation in the first 6MWT was 2.5+/-4.5%, and in the second test it was 1.8+/-4.0%. The mean difference between the first and second test was 0.6%, and the coefficient of variation was 104%.
Although the 6MWT distance was reproducible, the wide limits of agreement exceeded the minimum important difference for this test. These findings indicate that, in the routine evaluation of CF patients, at least two 6MWTs are required on any testing occasion to obtain a reliable estimate of the 6MWT distance.
确定囊性纤维化（CF）青少年和成人的 6 分钟步行测试（6MWT）的可重复性。
这是一项前瞻性的横断面研究。我们纳入了年龄>15 岁并参加成人 CF 项目的连续患者。患者接受了 6MWT、肺功能测试和临床评估。在休息 60 分钟后进行第二次 6MWT。
共纳入 31 例患者。平均年龄为 23.5+/-6.7 岁，平均 FEV1 为预计值的 61+/-28%。第一次 6MWT 中平均行走距离为 583.6+/-68.6m，第二次为 590.0+/-72.2m。第一次和第二次 6MWT 之间的平均差异为-6.5m，一致性界限为-74.9m 和 61.9m，变异系数为 4.3%。第一次 6MWT 中平均氧饱和度下降为 2.5+/-4.5%，第二次为 1.8+/-4.0%。第一次和第二次测试之间的平均差异为 0.6%，变异系数为 104%。
尽管 6MWT 距离具有可重复性，但广泛的一致性界限超过了该测试的最小重要差异。这些发现表明，在 CF 患者的常规评估中，在任何测试场合至少需要进行两次 6MWT，以获得 6MWT 距离的可靠估计。
