六分钟步行试验 Z 分数：与囊性纤维化严重程度标志物的相关性。
Six minute walk test Z score: correlations with cystic fibrosis severity markers.
机构信息
Pulmonology Division, Instituto da Criança, Hospital das Clínicas, University of São Paulo, Av. Dr. Enéas Carvalho de Aguiar, 647, zip code 05403900, São Paulo, Brazil.
出版信息
J Cyst Fibros. 2012 May;11(3):253-6. doi: 10.1016/j.jcf.2011.11.009. Epub 2011 Dec 20.
BACKGROUND
The six-minute-walk-test (6MWT) has been increasingly used in cystic fibrosis (CF) patients. However, few studies in children have correlated 6MWT with current parameters used to evaluate CF severity. Moreover, no study transformed the values of distance walked from meters into Z scores to avoid bias like age and gender, which are sources of 6MWT variability.
METHODS
A cross-sectional descriptive study was performed to analyze the correlations (Spearman) among forced expiratory volume in one second (FEV(1)), body mass index (BMI), chest radiography (CXR), chest tomography (CT), and 6MWT Z score (Z-6MWT). Clinically stable CF patients, aged 6-21 years, were included.
RESULTS
34 patients, 14F/20M, mean age 12.1±4.0 years were studied. The mean Z-6MWT was -1.1±1.106. The following correlations versus Z-6MWT were found: FEV(1) (r=0.59, r(2)=0.32, p=0.0002), BMI Z score (r=0.42, r(2)=0.17, p=0.013), CXR (r=0.34, r(2)=0.15, p=0.0472) and CT (r=-0.45, r(2)=0.23, p=0.0073).
CONCLUSIONS
In conclusion there was a significant, but poor, correlation between the six minute walk test Z score and the cystic fibrosis severity markers currently in use.
背景
六分钟步行试验（6MWT）已在囊性纤维化（CF）患者中得到越来越多的应用。然而，在儿童中，很少有研究将 6MWT 与目前用于评估 CF 严重程度的参数相关联。此外，尚无研究将距离行走的米数转换为 Z 分数，以避免年龄和性别等导致 6MWT 变异性的偏差，这些偏差是 6MWT 的来源。
方法
进行了一项横断面描述性研究，以分析一秒钟用力呼气量（FEV（1）），体重指数（BMI），胸部 X 线摄影（CXR），胸部计算机断层扫描（CT）和 6MWT Z 评分（Z-6MWT）之间的相关性（Spearman）。包括年龄在 6-21 岁之间的临床稳定 CF 患者。
结果
研究了 34 例患者，14 例女性/20 例男性，平均年龄为 12.1±4.0 岁。平均 Z-6MWT 为-1.1±1.106。与 Z-6MWT 相关的是：FEV（1）（r=0.59，r（2）=0.32，p=0.0002），BMI Z 评分（r=0.42，r（2）=0.17，p=0.013），CXR（r=0.34，r（2）=0.15，p=0.0472）和 CT（r=-0.45，r（2）=0.23，p=0.0073）。
结论
总之，六分钟步行测试 Z 评分与目前使用的囊性纤维化严重程度标志物之间存在显著但较差的相关性。
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