[生药各种甲醇提取物对大鼠α-萘基异硫氰酸酯诱导的实验性肝损伤的保护作用]
[Protective effects of various methanol extracts of crude drugs on experimental hepatic injury induced by alpha-naphthylisothiocyanate in rats].
作者信息
Kumazawa N, Ohta S, Tu S H, Kamogawa A, Shinoda M
机构信息
Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
出版信息
Yakugaku Zasshi. 1991 Mar;111(3):199-204. doi: 10.1248/yakushi1947.111.3_199.
Sixty seven methanol extracts of crude drugs were examined for their effects to protect hepatic injury induced by alpha-naphthylisothiocyanate (ANIT) in rats. In terms of the release of intrahepatic enzymes and bilirubin into the serum, 19 extracts were found to suppress the increase in the concentration of serum bilirubin by ANIT. Out of the 19 extracts those of Berchemia Racemosa Caulis, Aurantii Nobilis Pericarpium, Polygoni Avicularis Herba and Gentianae Scabrae Radix, also inhibited the release of several intrahepatic enzymes used as parenchymal injury parameter.
检测了67种生药的甲醇提取物对α-萘异硫氰酸酯（ANIT）诱导的大鼠肝损伤的保护作用。就肝内酶和胆红素释放入血清的情况而言，发现19种提取物可抑制ANIT引起的血清胆红素浓度升高。在这19种提取物中，光枝勾儿茶茎、化橘红、扁蓄和龙胆根的提取物还抑制了几种用作实质损伤参数的肝内酶的释放。
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