Ishizuka O, Kumazawa N, Ohta S, Kamogawa A, Shinoda M
Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Yakugaku Zasshi. 1992 Mar;112(3):174-82. doi: 10.1248/yakushi1947.112.3_174.
The effects of 5 crude drugs (Myricae Cortex, Polygoni Avicularis Herba, Hyperici Erecti Herba, Forsythiae Fructus, Desmodii Herba) on subacute and chronic hepatic injuries induced by carbon tetrachloride (CCl4) or alpha-naphthylisothiocyanate (ANIT) were investigated in rats. All of these crude drugs suppressed significantly the increase of several biochemical parameters with CCl4-injection twice per week for 4 weeks. Polygoni Avicularis Herba and Desmodii Herba among 5 crude drugs also protected the subacute hepatic injury induced by ANIT-injection for 4 weeks. In addition, the therapeutic effect of Desmodii Herba on the chronic hepatic injury induced by CCl4-injection for 9 weeks was recognized. Desmodii Herba has protective effects on the acute and subacute hepatic injuries induced by CCl4 or ANIT and an improving effect on the chronic injury induced by CCl4. Though the increase of hydroxylproline content in the liver began 4 weeks after the CCl4 or ANIT treatment, every crude drug had no significant effect against the liver fibrosis in these study.
研究了5种中药材（杨梅树皮、萹蓄、地耳草、连翘、鸡眼草）对四氯化碳（CCl4）或α-萘异硫氰酸酯（ANIT）诱导的大鼠亚急性和慢性肝损伤的影响。所有这些中药材均显著抑制了每周两次注射CCl4共4周后几种生化参数的升高。5种中药材中的萹蓄和鸡眼草也对注射ANIT共4周诱导的亚急性肝损伤具有保护作用。此外，还确认了鸡眼草对注射CCl4共9周诱导的慢性肝损伤的治疗效果。鸡眼草对CCl4或ANIT诱导的急性和亚急性肝损伤具有保护作用，对CCl4诱导的慢性损伤具有改善作用。尽管在CCl4或ANIT处理4周后肝脏中羟脯氨酸含量开始增加，但在这些研究中每种中药材对肝纤维化均无显著影响。
